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VOL. 10, ISSUE 3 (2025)
Zebrafish as a model for studying insect-borne diseases: A comprehensive review
Authors
Chetan P Warude, Chaitali Kulkarni, Dipak S Aher, Prachi P Bhosale, Yogita V Ahire
Abstract
Insect-borne diseases, counting malaria,
dengue, chikungunya, and leishmaniasis, pose noteworthy worldwide health
challenges, requiring innovative research models for understanding pathogenesis
and creating effective treatments. This review investigates the utility of
zebrafish (Danio rerio) as a model organism for studying these diseases,
highlighting its natural and genetic advantages over conventional models like
mice and rats. Zebrafish show fast improvement, transparent embryos, and
genetic similarities to humans, making them a important tool for exploring
host-pathogen interactions, drug screening, and vaccine development. The review
examines the classification and challenges of major insect-borne diseases,
emphasizing how zebrafish contribute to the study of particular pathogens. By
detailing their applications in malaria, dengue, and other diseases, this work
underscores the growing significance of zebrafish in infectious disease
research. Finally, future research directions are proposed to further enhance
their potential as a model for studying insect-borne diseases and progressing
therapeutic strategies.
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Pages:108-115
How to cite this article:
Chetan P Warude, Chaitali Kulkarni, Dipak S Aher, Prachi P Bhosale, Yogita V Ahire "Zebrafish as a model for studying insect-borne diseases: A comprehensive review". International Journal of Entomology Research, Vol 10, Issue 3, 2025, Pages 108-115
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