The current study was conducted to study the effects of ivermectin and moxidectin on the Psoroptic mite infection in calves from Al-Diwaniyah Province, Iraq. The experiment included the use of 15 animals (6-10 months old and 100-120 kg of body weight), randomly divided into three groups (five animals per a group); An ivermectin (IM) group, in which IM was given subcutaneously (S/C) at 5ml/calf, a moxidectin (MD) group, in which MD was administered S/C at 5ml/calf, and a control (CL) group, in which no treatment was used. Skin scrapings and blood parameters, including complete blood count (CBC) and erythrocyte sedimentation rate (ESR), were used, for which blood samples were collected from all calves at before the treatments and 8, 16, and 24 days after treatments. The results showed that skin lesions disappeared after treatment for both acaricides, which was confirmed by the presence of no mites in the skin scrapings collected for each time point after treatment. Hemoglobin (Hb) was elevated significantly (p˂0.05) after treatment in both treatment groups. Erythrocytes also revealed significant (p˂0.05) increases after treatment in both treatment groups. For the leukocytes, the findings revealed significant (p˂0.05) correction in their counts after treatment in both treatment groups. For eosinophils, MD showed a significant (p˂0.05) effect in normalizing the levels of these blood cells but only after 24 days of treatment. In the case of monocytes, MD showed a significant (p˂0.05) effect in decreasing the percentage of these cells after 8 and 16 days of treatment. No significant (p˃0.05) effects were seen in the cases of lymphocytes, neutrophil segmented nucleus, granulocytes, and ESR. The study provides important information regarding the treatment effects of ivermectin and moxidectin not only against mites but also in the case of correcting blood parameters of calves, especially when moxidectin was used.