Flesh fly Sarcophaga ruficornis causes myiasis and also serves as a vector for mechanical transmission of pathogens (trophozoites, helminth eggs). This study evaluates the histological effects of lethal concentration of deltamethrin and chlorpyrifos insecticide on the nervous system of flesh fly S. ruficornis in the laboratory. After being exposed to deltamethrin (0.001% and 0.003%) and chlorpyrifos (0.001% and 0.002%), adult flies mortality was recorded after 24 and 48 hours. To estimate insecticide toxicity, LC50 values were calculated using probit analysis. In both insecticide treatments, mortality rose with concentration and span of exposure. Deltamethrin produced mortality ranging from 29–41% at 24 hours and 37–50% at 48 hours, whereas chlorpyrifos caused mortality ranging from 24–38% at 24 hours and 34–48% at 48 hours. After 48 hours, LC50 values decreased, signifying that extended contact increases toxicity. Haematoxylin and eosin staining of the brain and thoracic ganglia revealed neurodegeneration, vacuolization, and neuropile degeneration in treated flies, while normal tissue organization was seen in control groups. The outcomes obtained specify that the population of this fly can be controlled by using deltamethrin and chlorpyrifos insecticide.