Honey bees are “Golden insects” that make honey and other essential honey bee products. Honey is the best-known primary product of honey bees, pollen, propolis, beeswax, royal jelly, apilarnil, bee bread are also marketable bee products. Bee products have been used by humans to cure and prevent a wide range of maladies. The use of bee products to strengthen immunity, protect and enhance health and support the treatment of certain diseases is known as apitherapy. These products have long served as both foodstuffs and remedies from healing of wound to anticancer effect due to the presence of nutrient rich composition. Honey has antibacterial and wound healing properties, whereas patients with diabetes are treated with propolis. Pollen is frequently applied on burns, allergies, and widely used to make cosmetics. Royal jelly is used to promoting reproductive health and to treat neurological diseases. Beeswax effectively acts as a coating for slow, controlled drug release. Bee venom is applied to treat the neuralgia, Parkinson’s disease and cancer. Apilarnil and bee bread are used for their advantageous effects on people. Some of the most significant medical applications of honey bee products are reviewed in this paper.