ARCHIVES
VOL. 11, ISSUE 1 (2026)
Chitosan extracted from Periplaneta Americana (American Cockroach): Characterization and its application as a novel excipient in sustained-release drug tablets
Authors
Dr. Jay Prakash Singh, M d Sajid Ali, Mohan Prakash Sharma, Rahul Dev, Apeksha Singh
Abstract
This study investigates Periplaneta americana (American
cockroach) as a sustainable and functional source of chitosan (Pa-Ct) for
sustained-release oral drug delivery. Chitosan was extracted from insect
biomass via an optimized protocol of deproteinization, demineralization, and
deacetylation, yielding 13.2% of dry mass. Comprehensive physicochemical
characterization revealed that Pa-Ct possesses a high degree of deacetylation
(91.3%), elevated crystallinity (68.5%), superior thermal stability, and a
fibrous, porous morphology compared to commercial shrimp-derived chitosan
(Sh-Ct). Matrix tablets containing theophylline were prepared using Pa-Ct as
the release-retarding polymer. In vitro drug release studies
demonstrated that Pa-Ct-based formulations provided more prolonged and linear
release profiles (78.2% over 12 h) than Sh-Ct counterparts (88.5%), with
release kinetics following an anomalous transport mechanism dominated by polymer
swelling and diffusion. The results establish Pa-Ct as a high-performance,
sustainable excipient with superior swelling capacity and gel-forming ability,
offering a viable and functionally enhanced alternative to conventional
chitosan for controlled-release pharmaceutical applications.
Download
Pages:300-307
How to cite this article:
Dr. Jay Prakash Singh, M d Sajid Ali, Mohan Prakash Sharma, Rahul Dev, Apeksha Singh "Chitosan extracted from <i>Periplaneta Americana</i> (American Cockroach): Characterization and its application as a novel excipient in sustained-release drug tablets". International Journal of Entomology Research, Vol 11, Issue 1, 2026, Pages 300-307
Download Author Certificate
Please enter the email address corresponding to this article submission to download your certificate.