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VOL. 11, ISSUE 1 (2026)
Bee Venom as a potential anticancer therapeutic: Clinical significance and mechanistic insights: A detailed review
Authors
Ajay kumar, Anubhav Dubey, Priyanshu Srivastava
Abstract
Toxins derived from diverse creatures have
been employed for many years in unconventional and Oriental medicine, with the
most research done on Apis mellifera venom. Bee venom's (BV) advantageous
qualities have been the subject of numerous investigations. Apitherapy, which
is mostly based on the experience using the traditional medical system in
various ethnic communities, is the use of honey and other honey-based products
to both prevent and treat diseases. The anticancer properties of BV, which are
mostly ascribed to its basic polypeptide melittin (MEL), are the subject of
numerous investigations nowadays. According to earlier research, BV and its
main component, MEL, have a substantial toxic effect on a variety of cancer
cells, including those of the liver, lung, my bladder, the kidneys, the
prostate, breast, and leukaemia, while normal non-target cells showed a less
noticeable effect. The phosphorylation of the phospholipase A2 enzyme (PLA2),
MAP kinase, and matrix metalloproteinases, which are proteins that kill cancer
cells is linked to their suggested mechanisms of action, which include effects
on proliferation along with development inhibition, cell cycle modifications,
and induction of cellular death through multiple cancer cell death mechanisms. A
variety of medications were given, such as phospholipase A2, melittin, crude
bee venom, and their complexes. In proportional to the dosage and duration, all
medications decreased the quantity of breast cancer cells. Cytotoxicity, the
death of cell targeting, and modulation of gene expression were among the
mechanisms of anticancer actions. Cell lysis. In summary, human breast cancer
cells are affected by the anticancer properties of bee venom as well as its
constituents. It is anticipated that using different vehicles will lessen side effects,
depending on how they work of anticancer actions. In the future, the venom from
bees and its constituents may be used in the prevention and treatment of breast
cancer.
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Pages:93-101
How to cite this article:
Ajay kumar, Anubhav Dubey, Priyanshu Srivastava "Bee Venom as a potential anticancer therapeutic: Clinical significance and mechanistic insights: A detailed review". International Journal of Entomology Research, Vol 11, Issue 1, 2026, Pages 93-101
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