Pomegranate (Punica granatum L.) is an important fruit crop in India. In Maharashtra, Nashik is leading in production, where the Mrig Bahar season (June–July) is vital. However, the pomegranate fruit borer, Deudorix isocrates, poses a significant threat, causing yield losses of 40–90% by infesting developing fruits. This study, conducted in Niphad Tehsil of Nashik district, during Mrig Bahar, studied the seasonal incidence of D. isocrates in two pomegranate orchards, monitored egg/larvae counts and fruit infestation rates (15–34% in Orchard 1, 12–25% in Orchard 2) across Standard Meteorological Weeks (SMW) 22–48. Weather parameters like temperature (20.1–36.1°C), rainfall (89.8–230 mm), and humidity (74.5–89%) were correlated with infestation levels.