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VOL. 11, ISSUE 1 (2026)
In Silico Analysis of Eriobotrya japonica Leaf Extract as an Acetylcholinesterase Inhibitor in Spodoptera litura
Authors
Yogesh Sharma, Dr. Anjali Dhar
Abstract
Spodoptera litura
is a destructive agricultural pest, and increasing resistance to synthetic
insecticides highlights the need for alternative control strategies. This study
investigates the acetylcholinesterase (AChE) inhibitory potential of Eriobotrya
japonica methanolic leaf extract against S. litura using GC-MS
profiling and in silico molecular docking. GC-MS analysis identified 59
phytochemicals belonging to fatty acids, terpenoids, phenolics, and chroman
derivatives. A three-dimensional model of S. litura AChE was generated
and validated for docking studies. Several phytoconstituents exhibited stronger
binding affinity toward AChE than the control ligand acetylcholine (-4.1
kcal/mol), with 13-docosenamide (-13.1 kcal/mol), 1-heptacosanol (-12.0
kcal/mol), and chroman derivatives showing the highest affinities. These
compounds interacted with key residues within the AChE catalytic pocket,
indicating effective inhibitory potential. Overall, the findings suggest that E.
japonica leaf extract is a promising source of natural AChE inhibitors and
may serve as an eco-friendly alternative for the management of S. litura.
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Pages:160-167
How to cite this article:
Yogesh Sharma, Dr. Anjali Dhar "In Silico Analysis of <i>Eriobotrya japonica</i> Leaf Extract as an Acetylcholinesterase Inhibitor in <i>Spodoptera litura</i>". International Journal of Entomology Research, Vol 11, Issue 1, 2026, Pages 160-167
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