ARCHIVES
VOL. 10, ISSUE 6 (2025)
Pennisetum setaceum extracts and copper nanoparticles: A potential solution for human pathogens and mosquito-borne diseases
Authors
Sarath kumar R, Raja P, Rajesh S
Abstract
The study investigates the green synthesis of
copper nanoparticles using Pennisetum setaceum extract, highlighting
their remarkable Mosquito larvicidal activity against Culex quinquefasciatus
larvae. The nanotechnology integration enhances bioavailability and cellular
penetration in C. quinquefasciatus larvae, boosting effectiveness at
lower concentrations. Copper nanoparticles (CuNPs) achieved 100% mortality at
≥100 ppm after 24 hours. Ethyl acetate extract caused 58.87% ± 1.56% mortality
at 150 ppm, while ethanol extract showed 64.90% ± 1.73% mortality at 120 ppm.
At 1000 ppm, CuNPs completely prevented hatching (0%), ethyl acetate extract
reduced it to 15.72%. Phytochemical screening of Pennisetum setaceum
extracts revealed the presence of tannins, saponins, flavonoids, and phenols in
both ethyl acetate and ethanol extracts, with cardiac glycosides detected only
in the ethanol extract. GC-MS analysis of the ethanol extract identified
neophytadiene (32.05%), benzenepropanoic acid (55.21%), and bis(2-ethylhexyl)
phthalate (12.74%) as major compounds. Ethanol extract and copper nanoparticles
(CuNPs) demonstrated significant antimicrobial activity against various
pathogens, with CuNPs showing the highest efficacy (inhibition zones up to
21.3±1.5 mm against V. cholerae and Aspergillus niger), MIC
values of 55.8-81% for ethanol extract and 69.2-82.9% for CuNPs, and MBC values
of 187.5-750 μg/ml for ethanol extract with E. coli being most
susceptible at 375 μg/ml. Toxicity tests using Artemia salina indicated
that P. setaceum extracts were less toxic than potassium dichromate,
with LC50 values of 801.23ppm for CuNPs and 730.81 ppm for ethanol
extract. These findings suggest that P. setaceum, a common weed, holds
potential for medicinal applications and mosquito larvicidal purposes and
warrants further investigation into pest management approaches.
Download
Pages:26-33
How to cite this article:
Sarath kumar R, Raja P, Rajesh S "<i>Pennisetum setaceum</i> extracts and copper nanoparticles: A potential solution for human pathogens and mosquito-borne diseases". International Journal of Entomology Research, Vol 10, Issue 6, 2025, Pages 26-33
Download Author Certificate
Please enter the email address corresponding to this article submission to download your certificate.