This study investigates the efficacy of Jatropha curcas-infused hermetic plastic bottles as a storage medium for maize grains (Zea mays), with a focus on pest control, grain preservation, and seed viability. The research aimed to assess the impact of Jatropha curcas infusion on five key storage quality parameters which include the survival rate of Sitophilus zeamais (maize weevil), weight retention of stored maize grains, percentage moisture retention, fungal load, and germination percentage post-storage. Maize grains were stored for 180 days period in both Jatropha curcas-infused and non-infused hermetic plastic bottles under controlled conditions. Results showed a significant reduction (0%) in the survival rate of S. zeamais in the J. curcas-infused containers compared to the control (90%) at eleventh day of infestation, indicating a potent insecticidal effect. Weight loss was also markedly lower (0.5%) in the J. curcas-treated storage, correlating with reduced insect and fungal damage. Moisture retention levels remained within the range of 99.77 to 84.54% in both storage types, although more stabilized in J. curcas-infused containers. Fungal load analysis revealed too few to quantify colony-forming units in the J. curcas-treated bottles, suggesting antifungal properties of J. curcas. Finally, germination tests indicated a higher percentage of viable seeds from grains stored in the infused containers with only 10% reduction recorded after 180 days of storage, affirming the method’s potential in preserving seed quality. These findings highlight Jatropha curcas-infused hermetic storage as a promising, natural alternative for maintaining maize grain integrity during storage, particularly in regions prone to post-harvest losses due to insect infestation and fungal contamination.