Background: Dengue is a significant global health concern, with India experiencing a marked increase in the number of cases. The primary vector, Aedes aegypti, has developed resistance to insecticides, undermining the efficacy of control programs.

Methods: This study evaluated the susceptibility of Aedes aegypti populations in Rajkot, India to commonly used larvicides and adulticides. Bioassays were conducted using field-collected larvae against Abate (Temephos) and Baytex 1000 (Fenthion), and adult mosquitoes were tested for Deltamethrin and Malathion. Commercial fumigants containing Cyfluthrin and Transfluthrin were also evaluated.

Results: The results showed that the mosquito population had significant resistance to the recommended field dosages of both organophosphate larvicides, Abate and Baytex 1000. Adult mosquitoes showed high susceptibility to deltamethrin (100% mortality) but high resistance to malathion (61% mortality). Commercial fumigants were largely ineffective, with a mortality rate of 65 %after 4 h.