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VOL. 10, ISSUE 12 (2025)
Apoptotic and histopathological biomarkers of gastropods in relation to nano-metallic nanoparticles exposure
Authors
Khaled Y Abdel-Halim, Ragab A Soliman, Reem M Ziada, Abdel-Hamid A Nahas, Hassien M Alnashiri
Abstract
Nanoparticles (NPs) will fit proliferation
their release into the environment getting up adverse outcomes. The present
study aims to evaluate apoptotic and histopathological defects of titanium
dioxide nanoparticles (TiO2NPs) and single walled-carbon nanotubes
(SWCNTs) in gastropod, Helix aspersa after exposure to sub-lethal dermal
doses for 48 h. The obtained data indicated that, response of apoptotic cells
to trypan blue dye conjugation with nucleus of the cells showed declines in
viability of the haemolymph of treated animals, respect to their control.
Treatment 0.1 TiO2NPs exhibited the greatest decline (71.33%),
respect to control (95.60%), followed by 0.1 SWCNTs (74.37%). This finding was
in parallel with significant increases in lactate dehydrogenase (LDH) activity
and level of carbonyl protein (CP) in haemolymph and digestive gland homogenate
of the treated individuals. Ultrastructure investigations in the digestive
glands of treated animals showed significant alterations in their components,
respect to firm structure of control sections, especially dilated microvilli
(MV) and vacuolated lysosomes (Ly) The present findings provide an ideal
illustrating potential cytotoxic effect of TiO2NPs and SWCNTs on the
treated snails. Also, the selected snail represents a reliable sentinel model
to assess the impacts of these NPs on the gastropods.
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Pages:145-152
How to cite this article:
Khaled Y Abdel-Halim, Ragab A Soliman, Reem M Ziada, Abdel-Hamid A Nahas, Hassien M Alnashiri "Apoptotic and histopathological biomarkers of gastropods in relation to nano-metallic nanoparticles exposure". International Journal of Entomology Research, Vol 10, Issue 12, 2025, Pages 145-152
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