The research compares the data of effects of humidity and temperature on infestation rates and growth rates of Sitophilus zeamais on Zea may of 5 different districts of India based on creating in-vitro conditions similar to the district of Karimnagar (Telangana), Ghaziabad (U.P.), Karnal (Haryana), Kapurthala (Punjab) and Bhilwara (Rajasthan). This re-analyzes quantitative description and information needed for predicting the infestation and growth rates in different environments. T1- Karimnagar (Telangana)- High temperature with high humidity showed the highest infestation and growth index amongst the others. However when the temperature was increased a gradual increase in the growth and infestation was seen. T4- Bhilwara (Rajasthan) High temperature with low humidity showed lowest infestation and lowest growth index amongst all the treatments. Hence, it is evident that if the stored grains are kept in dry and cold storage conditions there are less chances of the thriving of the pest. T5-. Kapurthala (Punjab) Average temperature with average humidity showed higher growth index and infestation than T4 only at 20-40% of humidity. However T5 was still showing less growth index and infestation than T1 in both the conditions which means other factors may affect the same.