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VOL. 9, ISSUE 5 (2024)
In vitro cytotoxicity activity of hexodecanoic acid extracted from red fire ant (Solenopsis Invicta)
Authors
Kavitha M, Poomani VM, Sharmila Banu G
Abstract
Breast cancer is a leading cause of death among women worldwide, and
current therapies have limitations and adverse effects. Bioactive compounds
found in natural sources have shown potential as alternative therapies. This
study aimed to evaluate the in vitro
cytotoxic activity of hexodecanoic acid extracted from red fire ants Solenopsis
invicta, particularly against breast cancer. Solenopsis invicta was isolated
using gas chromatography-mass spectrometry (GC-MS), and up to 11 bioactive
compounds were identified in the ethanolic extract. The MCF-7 cell line, known
for its hormone receptor expression, was used as a model to study breast
cancer. The MTT assay was used to evaluate the anti-breast cancer efficacy of
the bioactive compounds found in Solenopsis invicta. The bioactive compounds
extracted from Solenopsis invicta demonstrated significant cytotoxic activity
against MCF-7 and MDA-MB-231 cancer cells. The CTC50 value was 73.86 g/ml for
MCF-7 and 71.22 g/ml for MDA-MB-231. The study suggested that the Solenopsis
invicta ant extract has high anti-breast cancer efficacy on MCF-7 cells. The
results of the study suggest that bioactive compounds extracted from red fire
ants have potential as alternative therapies for breast cancer. Further
research is needed to identify the specific compounds responsible for the
observed anticancer properties and to determine their mechanisms of action.
Nonetheless, these findings provide a promising direction for future studies on
natural sources for cancer treatment.
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Pages:24-28
How to cite this article:
Kavitha M, Poomani VM, Sharmila Banu G "<i>In vitro</i> cytotoxicity activity of hexodecanoic acid extracted from red fire ant <i>(Solenopsis Invicta)</i>". International Journal of Entomology Research, Vol 9, Issue 5, 2024, Pages 24-28
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