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VOL. 9, ISSUE 12 (2024)
Impacts of diclofenac sodium on zebra fish (Danio rerio): A comprehensive review
Authors
Ejaz Rizvi Hussain, Shehnaz Siddika Rasid, Farmin Ahmed, Saif Afridi Hussain, Md Akib Hussain
Abstract
Diclofenac sodium, a widely used nonsteroidal
anti-inflammatory drug (NSAID), is increasingly recognized as an environmental
pollutant due to its persistence and bioaccumulation in aquatic ecosystems.
This study accumulates the comprehensive studies on the impacts of diclofenac
sodium on the model organism Danio rerio (Zebra fish), focusing on
physiological, biochemical, and behavioral alterations. Different studies have
suggested that significant hepatotoxicity, including altered liver morphology,
increased lipid peroxidation, and elevated levels of stress enzymes such as
catalase and superoxide dismutase. Behavioral analyses indicated reduced
locomotion and erratic swimming patterns, suggesting neurotoxic effects. The
findings underscore the ecotoxicological risks of diclofenac sodium to aquatic
life and highlight the urgent need for stricter regulations on pharmaceutical
discharges into water bodies. These study also establish zebrafish as a
sensitive bioindicator for assessing pharmaceutical contamination in aquatic
environments especially on fish population.
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Pages:1-8
How to cite this article:
Ejaz Rizvi Hussain, Shehnaz Siddika Rasid, Farmin Ahmed, Saif Afridi Hussain, Md Akib Hussain "Impacts of diclofenac sodium on zebra fish (<i>Danio rerio</i>): A comprehensive review". International Journal of Entomology Research, Vol 9, Issue 12, 2024, Pages 1-8
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