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VOL. 9, ISSUE 11 (2024)
In vitro assessment of antioxidant and cytotoxic effects of Sargassum wightii extract: Implications for disease prevention and cancer therapy
Authors
R Sangeetha, J Hemapriya, G Reshma, B Rajalakshmi, S Vijayanand
Abstract
Sargassum wightii,
a seaweed rich in bioactive phytochemicals, has garnered attention for its
potent antioxidant and cytotoxic properties. This study evaluates the
antioxidant and cytotoxic effects of Sargassum wightii aqueous extract utilizing
multiple in vitro approaches to comprehensively assess its
health-promoting potential. To quantify the antioxidant activity, multiple
assays were conducted, including DPPH radical scavenging, ABTS radical cation
decolorization, Ferric Reducing Antioxidant Power (FRAP) and assays targeting
superoxide, nitric oxide, and hydroxyl radical scavenging. The DPPH assay
revealed a significant reduction in free radicals, underscoring strong
antioxidant activity, while the FRAP assay highlighted the extract's capacity
for reduction. The ABTS assay further demonstrated effective ABTS radical
scavenging, and the superoxide, nitric oxide, and hydroxyl radical assays
showed a notable reduction in reactive species, reinforcing the extract’s
potential to mitigate oxidative stress. Additionally, cytotoxicity was
evaluated using the Brine Shrimp Lethality Assay, where an increasing dosage of
Sargassum wightii extract resulted in a progressive rise in lethality,
indicating the presence of cytotoxic compounds with potential applications in
cancer therapy. These findings underscore the therapeutic promise of Sargassum
wightii in oxidative stress-related disease prevention and cancer
treatment.
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Pages:234-240
How to cite this article:
R Sangeetha, J Hemapriya, G Reshma, B Rajalakshmi, S Vijayanand "<i>In vitro</i> assessment of antioxidant and cytotoxic effects of <i>Sargassum wightii</i> extract: Implications for disease prevention and cancer therapy". International Journal of Entomology Research, Vol 9, Issue 11, 2024, Pages 234-240
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