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VOL. 9, ISSUE 11 (2024)
Effects of ingestional exposure of 1,3,5-triazine derivatives on Drosophila melanogaster
Authors
Monika Yadav, Sunidhi Kashyap, Santosh Kumar Charan, Naresh Kumar Nirmal
Abstract
Triazines, specifically 1,3,5-triazine derivatives, have garnered
significant interest due to their diverse biological properties and potential
therapeutic applications, including anti-tuberculosis, antiviral, and
neuroprotective activities. This study investigates the effects of six
1,3,5-triazine derivatives on multiple life stages of Drosophila
melanogaster (Oregon-R strain) to assess their in vivo biological
impact. Using a high concentration of 1000 mg/L to capture acute effects,
parameters such as eclosion efficiency, gut integrity, oxidative stress,
mortality, morphological anomalies, and body weight were evaluated. Results
indicated that derivatives with halogen substitutions—2-fluoro (T2), 3-fluoro
(T3), and 4-chloro (T5)—caused significant developmental toxicity, marked by
pupal morphological abnormalities, increased oxidative stress, reduced eclosion
rates, and elevated mortality. Conversely, derivatives with unsubstituted
phenyl (T1), 2-trifluoromethyl (T4), and 4-bromo (T6) groups showed minimal
adverse effects. This study suggests that the type and position of substituents
on triazine derivatives play a crucial role in determining their biological
effects. Findings highlight the necessity for further research to elucidate
structure-activity relationships and optimize the safe application of
triazine-based compounds.
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Pages:76-83
How to cite this article:
Monika Yadav, Sunidhi Kashyap, Santosh Kumar Charan, Naresh Kumar Nirmal "Effects of ingestional exposure of 1,3,5-triazine derivatives on <i>Drosophila melanogaster</i>". International Journal of Entomology Research, Vol 9, Issue 11, 2024, Pages 76-83
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