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VOL. 9, ISSUE 11 (2024)
Assessment of cytotoxic and apoptotic activities of Assam propolis on Dalton’s lymphoma cell line
Authors
Trinayan Barthakur, Akalesh Kumar Verma, Namram Sushindrajit Singh, Saddam Hussain
Abstract
Propolis, a resinous substance collected by honeybees, has gained
significant attention for its wide range of biological activities. These
include antimicrobial, antioxidant, anti-inflammatory, immune-modulatory,
neuroprotective, and anticancer properties. In this study, we investigated the
cytotoxic effects of propolis collected from Assam, India, on Dalton’s lymphoma
(DL) cells over a 24-hour period. The findings revealed that Assam propolis
exhibits a dose-dependent cytotoxic effect on DL cells. As the concentration of
propolis increased, the cytotoxicity towards the DL cells also escalated. The
half-maximal inhibitory concentration (IC50) value, which indicates
the concentration required to inhibit 50% of the cell population, was
calculated to be 8.8±0.01 mg/ml. This suggests that Assam propolis has a potent
cytotoxic effect on DL cells at relatively low concentrations, making it a
promising candidate for further exploration as an anticancer agent. Given its
range of biological activities, including its newly confirmed cytotoxic
potential against DL cells, Assam propolis could serve as a valuable natural
product for developing cancer therapies. Further studies may be undertaken to
investigate its mechanism of action and its potential synergistic effects with
other anticancer agents.
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Pages:42-46
How to cite this article:
Trinayan Barthakur, Akalesh Kumar Verma, Namram Sushindrajit Singh, Saddam Hussain "Assessment of cytotoxic and apoptotic activities of Assam propolis on Dalton’s lymphoma cell line". International Journal of Entomology Research, Vol 9, Issue 11, 2024, Pages 42-46
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