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VOL. 9, ISSUE 11 (2024)
Evaluation of anti-bacterial, larvicidal, and cytotoxic properties of Moringa oleifera extracts
Authors
Balagangatharan P, Raja P, Ramkumar R, Rajesh S
Abstract
The emergence of antibiotic resistance has renewed interest in natural
antimicrobial compounds, with Moringa oleifera showing particular
promise due to its traditional medicinal applications. This study evaluated the
anti-bacterial efficacy, phytochemical composition, and cytotoxicity of various
M. oleifera extracts (seeds, flowers, leaves, and resin) using ethanol,
acetone, and methanol as solvents. The anti-bacterial activity was assessed
against six bacterial strains using the agar disc diffusion method. The ethanol
extract of resin demonstrated exceptional anti-bacterial activity against
Streptococcus mutans, achieving 76.2% effectiveness compared to the positive
control. GC-MS analysis identified hydroquinone (38.46%) as the predominant
compound in resin extract and benzeneacetonitrile, 4-hydroxy- (37.35%) in seed
extract. Cytotoxicity testing using zebrafish embryos revealed favorable safety
profiles with LC50 values of 416 mg for resin extract and 293 mg for seed
extract. Additionally, larvicidal and ovicidal assessments showed significant
vector control potential, with resin extract demonstrating superior efficacy
(LC50 = 451.62 ppm) compared to seed extract (LC50 = 485.99 ppm). The findings
suggest that M. oleifera extracts, particularly from resin and seeds, possess
promising anti-bacterial properties with a favorable efficacy-to-toxicity
ratio, warranting further investigation for potential therapeutic applications.
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Pages:59-65
How to cite this article:
Balagangatharan P, Raja P, Ramkumar R, Rajesh S "Evaluation of anti-bacterial, larvicidal, and cytotoxic properties of <i>Moringa oleifera </i>extracts". International Journal of Entomology Research, Vol 9, Issue 11, 2024, Pages 59-65
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