ARCHIVES
VOL. 9, ISSUE 10 (2024)
Molecular manipulation of insect genomes via CRISPR/CAS9 and their applications
Authors
Aminur Rahman, Bijumoni Borah, Pranab Borah, Saddam Hussain
Abstract
CRISPR technology has revolutionized the field of genetic engineering
and insect research, offering unprecedented insights into gene function,
functional genomics, and pest control. In model organisms like Drosophila melanogaster,
CRISPR knockouts have allowed for the study of specific gene functions,
contributing to advances in insect toxicology and resistance mechanisms. Gene
drives have emerged as a potent tool for pest management, enabling the rapid
spread of traits such as reduced fertility or pesticide susceptibility through
wild populations. This has potential applications for controlling disease
vectors like Aedes aegypti mosquitoes, which transmit dengue and Zika,
and Anopheles mosquitoes responsible for malaria. CRISPR is also
facilitating the development of biopesticides and overcoming insecticide
resistance in agricultural pests. Beyond pest control, the technology holds
promise for conservation, industrial biotechnology, and entomophagy. Insects
are being engineered as biofactories for pharmaceutical production and
optimized as sustainable food sources. However, concerns about off-target
effects, ecological risks, and public acceptance pose significant challenges.
Advances in CRISPR precision, alongside ethical and regulatory frameworks, are
essential for the responsible deployment of this transformative technology in
environmental and agricultural applications.
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Pages:189-196
How to cite this article:
Aminur Rahman, Bijumoni Borah, Pranab Borah, Saddam Hussain "Molecular manipulation of insect genomes via CRISPR/CAS9 and their applications". International Journal of Entomology Research, Vol 9, Issue 10, 2024, Pages 189-196
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