Malaria is a serious public health problem in India. Most of the malaria cases are reported from the tribal areas. Districts with 30% or more tribal population comprising about eight percent country’s population contributed to 46% of total malaria cases, 70% Plasmodium falciparum and 47% malarial deaths in the country. Six Anopheles species such as Anopheles baimaii, An. sundaicus, An. minimus, An. fluviatilis, An. stephensi, and An. culicifacies are primary malaria vectors in various eco-geographical regions in India. The secondary vectors i.e., An. annularis, An. nivipes, An. philippinensis, and An. varuna are also responsible to transmit malaria. According to published research articles approximately 42 of the totals 62 Anopheline species have been recorded in tribal areas of India. Use of long-lasting insecticide treated nets (LLINs) is the main malaria control strategy in all tribal areas, but lack of awareness and improper channelization of water bodies are also playing a key role to increase the larval breeding habitats. Outdoor biting of vector mosquitoes along with some other problems which are described in this article. “High burden to high impact” is a country-led approach that will be supported by WHO, the RBM Partnership to End Malaria and other partners.