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VOL. 8, ISSUE 12 (2023)
Inhibitory effect of Azadirachta indica phytochemicals against acetylcholinesterase (AChE) of Aedes aegypti (Diptera: Culicidae): A computational approach
Authors
Mudassir Alam, Kashif Abbas, Mohd Tanjeem Raza, Sana Asif, Shaizee
Abstract
The detrimental
environmental impact and collateral harm associated with synthetic insecticides
used in mosquito control programs underscore the urgent need for a paradigm
shift. Plant-based natural compounds emerge as a compelling alternative
demonstrating efficacy in mosquito control while mitigating ecological damage.
This transition to nature-derived solutions addresses immediate challenges and
signifies a crucial step towards sustainable and environmentally conscious pest
management practices. In this study, we employed computational tools to
meticulously evaluate the potential of phytochemicals derived from Azadirachta
indica as potent inhibitors of acetylcholinesterase, coupled with their
intrinsic insecticidal properties specifically against Aedes aegypti
mosquitoes. The analysis revealed a subset of compounds, particularly azulene,
squalene, mevalonic acid, hexadecanedioic acid, and neophytadiene,
demonstrating remarkable biological activity. These compounds exhibited dual
functionality as acetylcholinesterase inhibitors and effective agents with
insecticidal properties, as predicted by the PASS webserver. Further
substantiating their efficacy, the docking scores for these compounds were notably
favorable, ranging from -7.1 to -6.2 kcal/mol. These compelling findings
underscore the promising applicability of these phytochemicals in the targeted
control and management of Aedes mosquito populations, thereby addressing
the associated health risks and diseases.
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Pages:56-60
How to cite this article:
Mudassir Alam, Kashif Abbas, Mohd Tanjeem Raza, Sana Asif, Shaizee "Inhibitory effect of <i>Azadirachta indica </i>phytochemicals against acetylcholinesterase (AChE) of <i>Aedes aegypti</i> (Diptera: Culicidae): A computational approach". International Journal of Entomology Research, Vol 8, Issue 12, 2023, Pages 56-60
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