The purpose of this study is to investigate the anti-snake venom characteristics of plants endemic to the western ghats of India. It was observed that traditional healers in Maharashtra, India used these herbs to cure snakebite victims. The freeze-dried Daboia russelli snake venom was supplied by the Hindustan Snake Park in Kolkata. Botanists have identified and confirmed the Tamarindus indica and Cynodon dactylon species. Using three unique study models, including phospholipase A2 activity, procoagulant activity, and fibrinolytic activity, the leaves of both plants were extracted using a hot extraction method and then examined for in vitro antivenom activity. Plant extracts at 0.12 to 0.15 mg for Tamarindus indica and 0.15 to 0.18 mg for Cynodon dactylon reduced PLA2-dependent hemolysis, whereas plant extracts at 1.4 to 1.7 mg for Tamarindus indica and 1.7 to 1.95 mg for Cynodon dactylon neutralised coagulant activity. Tamarindus indica and Cynodon dactylon also showed fibrinolytic activity induced by Daboia russelli venom.