The study was aimed to control Sitophilus oryzae using Annona muricata and Syzygium samarangense plant leaf powder. Syzygium samarangense leaf powder had stronger repellent activity when compared to Annona muricata leaf powder. Annona muricata leaf powder has repellent efficacy of 49.33% in 5 gm concentration. Syzygium samarangense have repellent efficacy of about 55.33% in 5 gm concentration exposure. Identification of bioactive compounds and antimicrobial activities were carried out in Petroleum ether and Methanol leaves extract of Annona muricata and Syzygium samarangense through Gas chromatography mass spectroscopy and well diffusion method. The antimicrobial potential of Petroleum ether and methanol leaf extracts of the selected leaves were screened against eight species of bacteria. The maximum zone of inhibition in Petroleum ether and Methanol leaf extract of Annona muricata, were 1.15 ± 0.02mm, were on the observed zone of inhibition in Petroleum ether and Methanol leaf extract of Syzygium samarangense, were 1.22±0.04 and 1.05±0.02 respectively when compared to control. GC-MS analysis of Petroleum ether leaf extracts of Annona muricata leaves revealed the presence of various bioactive compounds like, Hexadecane, Caryophyllene, Pentadecane,1,2-Benzenedicarboxylic acid, Stigmas-4-En-3-One. GC-MS Analysis of Methanol leaf extract of Annona muricata leaves enabled presence of compounds like Neophytadiene, Dibutyl phthalate, 1,2- Benzenedicarboxylic Acid. The Petroleum ether leaf extract of Syzygium samarangense enabled presence compounds like Caryophyllene, Alpha-Sellinene, Beta selinene. Alpha -Sellinene, 1,2- Benzenedicarboxylic Acid, Disooctyl phtalate. The Methanol leaf extract of Syzygium samarangense showed compounds like Caryophyllene, Beta selinene, Alpha -Sellinene, Dibutyl phthalate, 1,2- Benzenedicarboxylic acid. These findings were focused in order to obtain data that would justify the possible use in the development of new drugs for various disorders and in controlling stored pests.