International Journal of Entomology Research

International Journal of Entomology Research


International Journal of Entomology Research
International Journal of Entomology Research
Vol. 7, Issue 5 (2022)

Indian Cobra (Naja naja) venom improves cognitive behaviour in Drosophila melanogaster


Sheeja S Rajan, Perumal Subramanian

The purpose of our research is to assess the anti-stress response of Naja naja venom and combinations of caffeic acid and para coumaric acid on the behavioral changes in Drosophila melanogaster under starvation for 36 h. Wild type flies were divided into eight groups and correspondingly, eight groups of starved flies (36h) were also maintained: (i) control and groups treated with – (ii) Naja naja venom (NNV), (iii) caffeic acid (CA), (iv) p-coumaric acid (PCA), (v) NNV+CA, (vi) NNV+PCA, (vii) CA+PCA, and (viii) NNV+CA+PCA. Cognitive behaviour (phototaxis, smell chemotaxis, taste chemotaxis, hygrotaxis, thermotaxis, and negative geotaxis) and status of redox homeostasis in flies were assessed in all groups of flies. Control flies showed normal cognitive behaviours and these behaviours are reversed in starved groups of flies. A tendency towards normalcy has been noticed in NNV/photochemical treatment. Although, the administered doses of NNV and combinations of CA, PCA could normalize cognitive behaviour and reduce oxidative stress the effects are maximum with NNV+CA+PCA treatment indicating that pharmacologically active small peptides present in snake venom (sarafotoxin, disintegrin, Kunitz-type inhibitor, natriuretic peptide, crotamine etc.) along with phytochemicals could evoke maximum preventive effect.
Download  |  Pages : 11-19
How to cite this article:
Sheeja S Rajan, Perumal Subramanian. Indian Cobra (Naja naja) venom improves cognitive behaviour in Drosophila melanogaster. International Journal of Entomology Research, Volume 7, Issue 5, 2022, Pages 11-19
International Journal of Entomology Research