Vegetable pests are one of the major biotic stresses that affect the production and productivity. Even if application of insecticides have been some how successful in managing the pest population, indiscriminate use of these harmful chemicals have been proved to cause deterioration of soil health, environment pollution and it also impairs animal health. At the same time, it also leads to development of resistance and resurgence issues which is now a major concern among the researchers. Hence at this point, breeding of crops to develop biotic resistant cultivars is one of the major ways to solve this problem. Genetic bases of pest resistance in vegetable crops and host plant resistance has greatly improved the efficiency of manipulating pest resistance genes in practical breeding programs which plays a great role to develop high-yielding genetically resistant cultivars. To develop resistant lines, source of resistance along with the genetic information is the basic essential part. Here, attempts have been made to provide a description on resistant sources of different vegetable crops against major insect pest, their inheritance, genetic manipulations, biotechnological interventions which will be useful in future breeding programme.