Honey bees are one of the most beneficial organisms for human beings. Bee hive products are interesting for their nutritional value and healing power. Honey is the most important product that is obtained from honeybees, however, many other products like wax, propolis, venom, pollen and royal jelly also have immense importance. Among all, propolis is of great medicinal importance, It is a natural composite resin which is collected by Apis mellifera from various plants. Propolis is collected by beekeepers however scientific methods of collection are still lacking. The propolis has been tested by various researchers for it’s therapeutic properties. It is mainly composed of polyphenol, flavnoids and quercetin substance which makes it medically important. During the present study, some of the medicinal activities were analyzed in Indian propolis obtained from Apis mellifera were analyzed. It was found that all the samples collected from different eco-climatic conditions possess therapeutic properties with varying amounts of polyphenols and flavnoids etc.