A study of the insecticide resistance status of Anopheles gambiae complex in Amechi Idodo, a rural community in Enugu State, was conducted from October, 2018 to November, 2020. The sampling of mosquitoes was done in all four villages (Eziobodo, Ohuani, Eziama and Obunagu) that make up Amechi Idodo community. Anopheles larvae were collected from diverse natural breeding sites including puddles, ditches rice fields, among others, with the aid of ladles, dippers and pipettes. They were reared to adults in the laboratory. Susceptibility of Anopheles gambiae to insecticides (DDT 4%, Pirimiphos-methyl 0.25%, Deltamethrin 0.05% and Bendiocarb 0.1%) was assessed using the WHO susceptibility test protocol. Susceptibility test showed that Bendiocarb recorded the highest mortality rate 98.75%, while DDT recorded the least 5.0%. Deltamethrin and pirimiphos-methyl recorded 8.75% and 10.0%, respectively. Anopheles gambiae was susceptible to only Bendiocarb. On the contrary, they were highly resistant to DDT, deltamethrin and pirimiphos-methyl. There is need for adequate insecticide resistance management to restrain the growing threat of insecticide resistance in Amechi Idodo.