Field experiments were conducted during 2020and2021 at the Plant Protection Research Station at Qaha region, Qalubiya Governorate, to study the effect of intercropping, fertilization on infestation of lima bean pod borer Etiella zinckenella on cowpea and evaluation of three chemical compounds to control it. Evaluation the efficiency of intercropping between cowpea and (Dill- Coriander- Jute mallow), the efficiency of fertilization Potakarb (K) and Folisil Calcium (Ca) at 300cm/100 L water were used. Also three chemical compounds [Egyxide plus (1000ml/100L water), Tebufenozide (75cm3/100L water) and Deltalym (320cm3/fed.)] were evaluated to control E. zinckenella. The lowest mean numbers of population densities of E. zinckenella were (0.05 and0.05 larvae/30 Pods) and (0.36and0.3 larvae/30 Pods) occurred in the case of intercropping (Cowpea+Dill) during 2020and2021 seasons on Cowpea’s green and dry pods, respectively. Deltalym showed the highest reduction(%) in larval population after the first and second spray(86.6and89.4%)and(84and91.9%)during 2020and2021 seasons on Cowpea’s green pods, respectively. whereas the reduction with the use of Tebufenozide showed maximum reduction in the first and second spray (61.5 and 65.8%) in the first season (63.2 and 64.4%) in the second one on Cowpea’s dry pods. Tebufenozide recorded the highest percent in total protein in cowpea grains during seasons 2020and2021. The highest yield of green pods was obtained in the intercropping of Cowpea+Dill in two seasons. The highest yield of dry pods was obtained in the case of treatment with Tebufenozide (635and600 kg/fed.) in the two seasons. The yield of dry pod resulting from the intercropping with Dill was highly protected from the infestation with postharvest insects in the two seasons.