Experiments were carried out to comparison between biological and chemical control on controlling Myzus Persicae (Sulzer) (Hemiptera: Aphididae) infesting tomato plants, Lycopersicon esculentum (var. Lopena) under plastic greenhouses at Dokki region, Giza Governorate during two seasons 2020, 2021. Biological control was carried out by using release the predator, The seven spotted lady beetle, Coccinella septempunctata L. (Coleoptera: Coccinellidae) at three levels of release (25, 50 and 75 eggs/plant). And chemical control was carried out by using three aphicides (Marshal, Malathion and Dimethoate). Releasing the predator and spraying the aphicides conducted on the beginning of March on tomato plants at both of the two tested seasons 2020, 2021. Data obtained at season 2020 showed that when we applied the three levels of release of the successive predator the reduction percentages in the population of M. persicae increased gradually whereas it were 23.9, 35.5, 46.8, 52.1 and 61.4% in mid-March, first-April, mid-April and first-May, respectively in the first level of release and were 27.9, 37.7, 47.5, 54.4 and 68.3% (at the same dates respectively) in the second level of release and were 29.9, 38.1, 48.7, 57.9 and 74.3% ( in the same dates respectively) in the third level of release. While in the chemical control when we use the three successive aphicides, the reduction percentages (the general effect percentages) of the tested aphicides (Marshal, Malathion and Dimethoate) arranged descending as follow: Marshal, Malathion and Dimethoate whereas the general affect percentages for them were 96.2, 95.1 and 94.6% respectively in season 2020. The same trend was achieved at the second season 2021 both in the two experiments (biological and chemical) control.