The development of resistance to synthetic insecticides among insects and their impact on the environment and humans forced research toward Phyto-insecticides. Although many plants have been explored and their secondary metabolites screened for anti-insect properties, it is still worthier to continue the search as only a minuscule of the secondary metabolite repertoire has been exploited till now. Leaves of Cleistanthus collinus (Roxb.) Benth. ex. Hook. f., (Fam.: Euphorbiaceae) was powdered, extracted using acetone and chloroform and their insecticidal effect evaluated against Spodoptera litra Fab. The results revealed that both the extractives were effective in imparting insecticidal effect. Among them, chloroform extractive was found to be more effective than acetone. Chloroform extractive imparted maximum mortality of 66.67% at 5 % itself whereas the acetone extractive reached the maximum of 66.67% at 50 % concentration only. Hence, further development of emulsion formulation may be attempted with chloroform extractive.