This study cared out to evaluated the insecticidal and the residual effect of, thiamethoxam at 25WG 20/ 100littr, Acetamprid at 25 WG 25 gr/ 100 littr, lambadacyalothrin 5%EC at 375 cm/ feddan and profenonfps 72% EC 750 cm/ feddan under field conditions on Aphis gossypii and Bemisia tabaci and their side effects on the associated natural enemies during two consecutive seasons 2020 and 2021 Beni- suef Governorate in Egypt on cotton fields. The results showed that all the pesticides used had the most effect against Aphis, Aphis gossypii and Bemisia tabaci, after 24, 3-days, 7-days and 15-days of spray. Moreover, thiamethoxam, Acetamprid, lambadacyalothrin and profenonfps proved also reduction to the populations of Coccinella septempunctata and C. carnea. Also these results indicted to the initial and residual effect signification of these insecticides was highly lasting up to 15 days. From these results we suggested that, choosing suitable insecticide to control the tested cotton pests not only depends on its efficiency but also its toxicity to natural enemies.