Tortoise beetles, Cassida vittate, Vill., Coleoptera: Chrysomelidae is a dangerous sugar beet pest in Egypt that reduces output of both quantitative and qualitative traits. As a result, the farmers rush to apply pesticides to suppress this insect regardless of the economic threshold level. With the increased consciousness about the hazards of traditional chemicals in agriculture, a remarkable decrease in the use of pesticides and an increase in the use of biorational pesticides (insect growth regulators and biocide) were noticed. Biorational pesticides, known as "third-generation pesticides" are made from synthetic or natural compounds that effectively control insect pests, with no risk to the environment or farm animals. The current study was carried out in western Nubariyah, El- Beheira Governorate (Sugar beet area) during 2020/2021 and 2021/2022 seasons to evaluate the effect of three biorational pesticides (Hexaflumuron, Methoxyfenozide and Emamectin benzoate) compared with two traditional pesticides (Chlorpyrifos and Profenofos as organophosphates) against larvae and adults of C. vittata and their side effect on arthropod related predators. Concerning reduction percentage, the obtained results revealed that Chlorpyrifos and Profenofos were more toxicity pesticides against C. vittata population in both stages, while chitin synthesis inhibitors (hexaflumuron) and ecdysone agonists (methoxyfenozide) exhibited intermediate toxicity to target this insect. On the other hand, biocide pesticide (Emamectin benzoate) showed the lowest toxic effect. Moreover, the toxic effect of the used pesticides on the two insect stages (larvae and adults) was slightly similar with respect to the number of insects in various frequent inspection times after spraying and the reduction percentages. The results also indicated that the pesticides were the lowest toxic on the thirds day after spraying, then the efficiency of the lethal pesticides effect gradually increased until 21 days after spraying the pesticides in both stages (larvae and adult) of tortoise beetles. Further, data of the average overall inspection showed that reduction percentage for insect growth inhibitors, IGRs (hexaflumuron and methoxyfenozide) and biocide pesticides were safer for the studied total predators, Coccinella undecimpunctata (Linneus), Coccinella septempunctata (Reiche), Scymnus interruptus (Goeze), Paederus alfierii (Koch), Orius sp. and Chrysoperla carnea (Stephens) as compared to the traditional pesticides (Chlorpyrifos and Profenofos). Under conditions of the present study, the use of insect growth regulators and biocides pesticides (third-generation pesticides) that affect the hormonal regulation of molting and developmental processes in insects as one of integrated pest management (IPM) can be recommended for sugar beet pests, especially C. vittata considered safer for the biotic and abiotic conditions.