The present study aimed to evaluate the effectiveness of Moringa oleifera extract and nano selenium in reducing the levels of hepatic enzymes (AST, ALT) in diabetic rats. This study was conducted in the animal house / College of Science / University of Kufa and the study extended from 1/12/2021 to 1/6/2022. The study included the use of 250 mg/kg of MO and 0.4 mg/kg of SeNPs separately and a mixture of The two substances together as a combined treatment. The results showed a decrease in the level of glucose and liver enzymes in the groups treated with MO and SeNPs. The results also showed the highest therapeutic efficiency when using the two substances together as a joint treatment. The results of the histological study showed therapeutic effects on the liver after treatment with MO and SeNPs. We conclude from this study that Moringa oleifera and SeNPs are effective in treating diabetes.