The plant investigation has opened up a new respective biopharma research. Mangroves have been used in folk medicine for treatment of several. Compounds isolated from marine source have the chemical structures which are not commonly found in terrestrial counter parts. In recent years an increasing number of marine natural products have been reported to display antimicrobial compounds. The knowledge of chemical constituents of plants is desirable to understand herbal drugs and their preparation. In the present study suggests that the Hemidesmus indicus extract, significant implications in food and pharmaceutical industry as a source of basic material in the preparation of nutrient supplement products and fine chemical synthesis. The findings of this study revealed that the plant Hemidesmus indicus leaf extracts could be used as a potential alternative for development of bioactive leads in the treatment of infections.