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VOL. 6, ISSUE 5 (2021)
Betulinic acid and rotundic acid alleviates genotoxicity induced by mercuric chloride on blood lymphocytes of albino wistar rats
Authors
Muthaiyan Revathi, Ganesan Jagadeesan
Abstract
Mercury is an uncommon element present in the universe, known to be greatly dangerous in comparison to other heavy metals. Hg is highly toxic to the organisms, causing severe damages to most of the cells, tissues and organs. Thus, the present investigation was framed to find out the ameliorative efficacy of betulinic acid and rotundic acid on genotoxicity induced by mercuric chloride on blood lymphocytes of adult albino male rats. HgCl2 was given orally for 1.29 mg/kg of body weight of Albino wistar rats for 7 days and betulinic acid and rotundic acid (5mg/kg body weight) was dosed for another 7 days on intoxicated rats. The genotoxicity induced by HgCl2 was analyzed through comet assay and RT-PCR expression of 8-oxoguanine on blood lymphocytes of rats. The results revealed that betulinic acid and rotundic acid treatment significantly improved the defense system by enhancing their antioxidant properties and attenuate the DNA damage prompted by HgCl2.
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Pages:5-11
How to cite this article:
Muthaiyan Revathi, Ganesan Jagadeesan "Betulinic acid and rotundic acid alleviates genotoxicity induced by mercuric chloride on blood lymphocytes of albino wistar rats ". International Journal of Entomology Research, Vol 6, Issue 5, 2021, Pages 5-11
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