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VOL. 6, ISSUE 4 (2021)
in silico screening of phytocompound inhibitors against sterol carrier protein (AeSCP-2) in Aedes aegypti
Authors
K Sivasankaran, C Elanchezhiyan, Soliang Manyu, P Basker
Abstract
The major component for insect's growth is cholesterol, which is regulated by sterol carrier protein 2 (SCP-2). Naturally, the plants contain numerous active compounds, acting as inhibitors for proteins carrying sterols (AeSCP-2). Therefore, in the present study overall, 21 phytochemicals were selected from previously reported plants with insecticidal activity, i.e., Citrullus colocynthis (L.), Cannabis indica (L.) and Artemisia argyi (L.), and were utilized for dock (in silico) with the mosquito AeSCP-2. Among all the compounds, 1-Propanone, 3-(2-hydroxyphenyl)-1,3-diphenyl (methyl triphenyl acetate), 2-Isopropenyl-2,3-dihydrofuro[3,2-g] chromen-7-one and 4-Nitro-4'-chlorodiphenylsulfoxide yielded results with the lowest docking energy, i.e., -13.7362, -11.993 and -11.3161 Kcal/Mol, respectively. Among all the three compounds, methyl triphenyl acetate displayed the lowest binding energy score than others. It is also a major phytocompound found in Artemisia argyi extracts, and this plant might have displayed insecticidal activity due to the presence of methyl triphenyl acetate, which, based on the in silico studies, act as an AeSCP-2 inhibitor.
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Pages:257-261
How to cite this article:
K Sivasankaran, C Elanchezhiyan, Soliang Manyu, P Basker "in silico<em> </em>screening of phytocompound inhibitors against sterol carrier protein (AeSCP-2) in Aedes aegypti ". International Journal of Entomology Research, Vol 6, Issue 4, 2021, Pages 257-261
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