The North East India is a hotspot of biodiversity & ethnic inclusiveness which provide it a unique identity from the mainland India. Owing to the multiculturalism, entomophagy is one of the most popular practice among the tribal people across the region. The current study documented the macronutrient content i.e. protein, carbohydrate & fat content of total 18 popular edible insect species of the region. On comparison of the macronutrient content among the 18 species, the highest protein content is found to be in the giant water bug comprising 21.6% of its fresh weight whereas the wax moth revealed the highest amount of fat content comprising 22.1% of its fresh weight & the highest carbohydrate content is found to be in the insect house cricket containing 5.8% of the fresh weight. The study report also encompasses the name of 100 popular edible insect species across the region & listed the traditional therapeutic uses of various insects among the ethnic tribe of the region.