The study of arthropods including insects, arachnids, centipedes, millipedes and crustaceans, to criminal or legal cases is called as Forensic entomology.Chrysomya saffranea is the most important fly which is used for the estimation of the dead body and the post-mortem interval (PMI).It belong to family Calliphoridae and order Diptera. This is the first fly which comes on the vertebrate corpse due to the release of gases like puterecine because they seek a warm, moist protein-rich source to lay eggs. In the larval development the temperature and humidity play a major role in the estimation of time since death. This is the most forensically important fly known as blow fly. Blow flies are used as an entomological evidence for the estimation of death. This paper deals with the biology and life cycle of Chrysomya saffranea and their interaction with the corpse. In order dipteral Holometabolous metamorphosis takes place.