Bio-efficacy of various treatment schedules of micronutrient Zinc (Zn) and Boron (B), viz T1 (V2Zn0B0), T2 (V2Zn1B1), T3 (V2Zn1B0), T4 (V2Zn0B1), T5 (V1Zn0B0), T6 (V1Zn1B1), T7 (V1Zn1B0) and T8 (V1Zn0B1) were evaluated against aphid, Myzus persicae (Sulzer) (Aphididae: Hemiptera) in two potato variety, Kufi Chandramukhi (K.CM) and Kufri Jyoti (K.JT) during Rabi season of two consecutive years in 2017-2018 and 2018-2019 from November to February. The application in combination of both zinc and boron was most effective in reducing the population of aphid in both the cultivars of potato i.e. Kufri Chandramukhi and Kufri Jyoti. Therefore the cultivar Kufri Jyoti (T2) and Kufri Chandramukhi (T6), were recorded lower aphid infestation. The percentage of healthy tuber yield of K.JT and K.CM was found highest in T6 (81.43 – 82.47%) and T2 (78.93 – 80.75%) and found lowest in T5 (63.24 – 68.58%) and T1 (66.45 – 69.49%), respectively. Similarly percentage of tuber damage of K.JT and K.CM was noted highest in T5 (31.42 – 36.76%) and T1 (30.51 – 33.55 %) and it was lowest in T6 (17.53 – 18.57%) and T2 (19.25–21.07%), respectively. Among the different treatment schedules combined application of Zn and B in T2 and T6 revealed effective result in increasing marketable yield of potato tubers and reduction of aphid incidence over control T1 and T5 and also over other treatments.