Field experiments were carried on cotton during season 2020 at Al-Dakahlia and Al-Fayoum governorates, Egypt. Abamectin, Fenpyroximate, Buprofezin, were compared to a natural pesticidal product (Anti-insect) against all movable stages (immature and adults) of Tetranychus urticae by using two sprayers, a Motorized Knapsack motor (Cifarilli) (20 L. /Fed.) and a Hydraulic sprayer (Matabi) (56 L. /Fed.). The residual behavior of the tested acaricides was evaluated in cotton seeds, and the intercrops, cucumber, and tomato fruits loaded under early cotton stages in the field. All tested compounds induced a significant negative efficacy on T. urticae survival. Abamectin and Fenpyroximate exhibited the highest acaricidal activity, followed by Buprofezin and Anti-insect. Cifarilli sprayer was more effective to control T. urticae on cotton according to the homogeneity of the droplet spectrum. The Cifarilli' rate of performance (Fed. /day) was 4 times that Matabi sprayer. The lost spray-on ground for the Cifarilli motor was lower than Matabi sprayer with 40%. All cotton seed samples were free from residues of the pesticides. The recovery rate of Abamectin, Fenpyroximate, and Buprofezin from the fortified samples of cucumber, and tomatoes fruits ranged from 83.07% to 92%. The pre-harvest interval period was (10 and 4 days), (10 and 10 days) and (6-7 and 6 days) for tomatoes and cucumbers with Abamectin, Fenpyroximate, and Buprofezin, respectively. There were no significant differences between the effects of using the two sprayers on the safety period for the pesticides investigated, due to similarity in the pesticide degradation for sprayers and governorate.