This study aimed to investigate the insecticidal activity of Chlorogenic acid and Caffeine extracts from Green Coffee Beans against the cotton aphid, Aphis gossypii Glover (Hemiptera: Aphididae) and two spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae) in Agriculture research farm, during season April 2020. Mixtures of water-solvents were applied for extraction of Chlorogenic acid and Caffeine in good yield. The two extracts were characterized by Micro elemental analyses, melting point, pH and solubility measurements. Five concentrations were applied for each extracts (500,1000,2000,3000,6000 ppm). The extracts tested significantly reduced the pest population compare to control. The result showed that Chlorogenic acid extract was more effective than Caffeine extract against Tetranychus urticae Koch (100.0, 49.8%). While, Caffeine extract was more effective than Chlorogenic acid extract against Aphis gossypii Glover (100.0, 37.7 %) respectively. The extracts insecticidal activity was increased by increasing concentration and their effects against the cotton aphid and spider mite were dependent on acidity and solubility values of their treatment solutions.