Malaria is a world-wide public health issue caused by protozoan parasite plasmodium, which is comparatively endemic in Pakistan. From 1 August 2017 to 31 July 2018, the specific research was conducted to evaluate the prevalence of Plasmodium infection in Quetta (town). 33 Quetta schools were visited twice a month and 2213 blood slides were taken, 433/2213 of which were positive. However, the most common species recorded was P. vivax with the considerably high incidence levels (84.52%) relative to P. falciparum (6.01%) and mixed infection (12.29%). In month of august, frequency rate of malarial infection was highest (91.6%) and lowest in March (57.1%). The data was analyzed statistically to check any sort of correlation between gender and types of malaria infection and also difference between types of malaria infection as well as the months of the year. The prevalence of malaria infection was substantially high in males (76.44 %) compared to females (23.55 %). Such a high occurrence of vector borne disease malaria, in children of Quetta exhibit that malaria poses a significant health problem in that particular area, thereby Government and Health Consultants should pay attention for preventing and controlling the infection in children of Quetta city.