House flies are vectors for many pathogens and hence medically important pest too. The control of flies is a challenge. The use of chemical insecticides is this regards though effective has not solved the problem. The intensive use of broad-spectrum insecticides against M, domestica has led to the development of resistance to many registered pesticides use for its control. Thus it is necessary to find a new safe and cheap alternative to manage fly populations. Plant products as an alternative to conventional chemical method have now been established worldwide. The purpose of the present study is to find out a plant based inhibitor for the digestive enzymes of this pest. The physiology and biochemistry of the insect digestive enzyme has an important role in the study of novel insecticidal strategies. Thus in this study two plant extracts have been assessed for their α-amylase inhibitory activity of house adult and larvae.