Effects of sildenafil citrate and diazepam on developmental stages of forensically important fly: Chrysomya albiceps (Diptera: Calliphoridae)
Mohamed Elshehaby, Mahran Tony, Nora Z Abdellah, Abd Elbaset MA Abd Elreheem
The blowfly Chrysomyaalbiceps is a member of Calliphoridae that feed on the carrion, garbage and feces. Chrysomyaalbiceps are most commonly associated with corposes. Chrysomyaalbiceps was reared on three groups of rabbit tissues administered (group Sildenafil citrate (SC or Viagra) an over dose of 10.26 mg/kg and group Diazepam an over dose of 4.06 mg/kg each of drugs dissolved in distilled water, by intra-peritoneal injection twice daily for one week. The control group was reared on rabbits injected with Distilled water. Residue of Sildenafil citrate and Residue Diazepam concentrations from both treated and control groups in some tissues of rabbit and third larval stage, pupae, adult Chrysomya albiceps were analyzed by high performance liquid chromatography (HPLC). Concentrations of this drugs in larval stage, pupae, adult were lower than those found in tissues rabbit. The developmental time for total durations life stage in treated carcasses were the longest at than the control. The life cycle Chrysomya albiceps increased gradually by adaptive for the two treated groups and decrease gradually by adaptive for control group in F 2 and F3. The durations of stages that fed on control carcasses was less time than diazepam, sildenafil respectively. These results indicate that (SC) and Diazepam retard larval development.
Mohamed Elshehaby, Mahran Tony, Nora Z Abdellah, Abd Elbaset MA Abd Elreheem. Effects of sildenafil citrate and diazepam on developmental stages of forensically important fly: Chrysomya albiceps (Diptera: Calliphoridae). International Journal of Entomology Research, Volume 5, Issue 1, 2020, Pages 82-89