This research was conducted to assess the impact of single visit of Apis mellifera on fruit and seed yields of Bixa orellana, its foraging and pollinating activities were studied in Ngaoundere from June to July 2010 and 2011. Treatments included unlimited flowers access by all visitors, bagged flowers and flowers limited visits by A. mellifera only. The foraging behavior of A. mellifera on flowers and its pollination efficiency were recorded. Apis mellifera was the most frequent visitor and it intensely and exclusively collected pollen. The fruiting rate of unprotected flowers is significantly higher than those of where insects were excluded. Through its pollination efficiency, A. mellifera provoked a significant increase of the fruiting rate by 74.10% and 33.25%, the percentage of the number of seeds per fruit by 85% and 28.8% and the percentage of normal seeds by 70.18% and 43.20% in 2010 and 2011 respectively. Conservation of A. mellifera colonies close to B. orellana fields is recommended to improve fruit and seed production in the region.