The toxic effect and persistence of (Aerosil^®) silica nanoparticles were conducted against Sitophilus granarius (L.) and Rhyzopertha dominica (F.) adults at the laboratory condition (26 ± 2°C and 60 ± 5 RH). (Aerosil^®) were applied at 4, 1, 2, 0.5, and 0.25 g/kg on wheat and paddy rice seeds. Results revealed that Aerosil^® has high toxicity on both species, Aerosil^® at 4 g/kg on wheat and paddy rice gave complete mortality (100.0%) after 7days exposure period against tested insect species. Meanwhile, complete reduction in F1-progeny of S. granarius was observed at the two highest used concentrations and R. dominica at the three highest concentrations on wheat, also complete inhibition in F1-progeny of both tested species was achieved at the three highest concentrations on paddy rice. Serum samples of albino rats results showed that, Aerosil^® did not alter activity of (TNF-α), (MDA) and (CEA) in rats fed on treated wheat grains.