There has been much interest in recent years in understanding the mechanism and effects of the exercise in aged people. However, it is not clear whether or not aging influence the ability of the muscle to respond to training. There have been reports of the decline in the activity of muscle proteins in aged animals due to hypertrophy. In the present study, the result confirms the hypothesis that the muscle activity declines with age. There is a decrease in the total proteins and glycogen in the older animals when compared to younger animals indicating reduced synthetic rate and increased catabolic rate of proteins. This is also attributed to the neural factor which may be one of the reasons for reduced hypertrophy in aging animals.