Assessment of primary skin irritation in New Zealand white rabbit and skin sensitization in dunkin hartley guinea pigs after topical application due to penoxsulam herbicide

Vidushi Chaurasia; Madan Lal Aggarwal; Manoj Chandra Garg

Assessment of primary skin irritation in New Zealand white rabbit and skin sensitization in dunkin hartley guinea pigs after topical application due to penoxsulam herbicide

Authors
Vidushi Chaurasia, Madan Lal Aggarwal, Manoj Chandra Garg

Abstract
Process of making sensitive or hypersensitive allergic sensitization of the skin is a part of the normal immune reaction of the body in response to the presence of a foreign compound. The rabbit and guinea pig as a sensitive and reasonable alternative to larger mammals for toxicity of variety of drugs for human being safety evaluation. The primary skin irritation (PSI) and Skin sensitization toxicity potential of a herbicide, penoxsulam, were evaluated in rabbit (New Zealand white) and guinea pigs (Dunkin Hartley) with compliance with OECD guideline. To evaluate dermal irritation, the topical patch was attached to the rabbit skin by using penoxsulam for four hour and test site was observed for 72 hours, resulting that no skin reaction such as erythema (redness of skin) and edema (swallowing of the skin) were observed in all the rabbit in whole experiment. In skin sensitization experiment, guinea pigs were topically exposed to positive control, negative control and treated with penoxsulam herbicide for 6 h in induction and challenge phase. Serious sensitization was noticed in the positive control group whereas, no erythema and edema reactions were shown in the negative group as well as treated group (penoxsulam). With all together, these findings agreed that penoxsulam completely not produce primary skin irritation and skin sensitization among animals and appears to be safe for acute and repeated use on environment.

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